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Applied Biosystems Updates Investors at Merrill Lynch Conference

February 6, 2007--Dennis Winger, executive vice president & chief financial officer of Applera Corporation, gave an update on Applied Biosystems' (ABI) operations at the 2007 Merrill Lynch Global Pharmaceutical, Biotechnology & Medical Device Conference. During his presentation, Winger highlighted recent achievements as well as a number of growth initiatives ABI has been developing and executing over the past two years.

With 2006 revenues of over $1.9 billion, ABI met nearly 12% of the total addressable market serviced by three of its four divisions; Molecular & Cell Biology, Proteomics & Small Molecule, and Applied Markets had approximate market sizes for fiscal year 2006 of $7 billion, $2 billion, and $7 billion, respectively.

Says Winger, future growth of Molecular & Cell Biology (with a projected 3-year growth rate of 5–8%) will be driven by: 1) stabilization of the sequencing market during the current fiscal year following a period of decline — the first half of fiscal year 2007 saw 4% growth. Beyond this fiscal year, modest growth across sequencing is projected; 2) the continued adoption and utilization of real-time PCR and TaqMan consumables for purposes of research and clinical validation; and 3) the ability to leverage ABI's existing installed base of instruments to provide more value-added consumables to customers and capture a greater percentage of the overall workflow.

Growth across Proteomics & Small Molecule (with a projected 3-year growth rate of 5–8%) is expected to be driven by: 1) continued momentum within biomarker discovery research; and 2) continued demand for greater sensitivity for the detection of metabolites in preclinical and clinical studies.

Continued growth in Applied Markets (with a projected 3-year growth rate of 10–15%) relies on: 1) further expansion of ABI's DNA forensic business both domestically and internationally; 2) continued development of its quality and safety test business for environmental and food testing as well as pharmaceutical QA/QC; and 3) expansion of its biosecurity business for detection and surveillance of infectious disease and potentially harmful chemical threats.

Moving forward, ABI has many key growth initiatives designed to continue its momentum. Its primary focus is to drive growth through providing differentiated applications based on solutions that its customers need. In addition, ABI plans to expand its consumables product lines to drive more sales across its existing installed base of instruments. Notably, the company is on track to develop and commercialize a next-generation sequencing instrument. It will also continue to expand and cultivate the applied markets including forensics, quality/safety, and biosecurity. Finally, ABI will continue to invest in high-growth emerging markets including China, India, Russia, and Latin America.

Improved capital management has increased ABI's ability to generate cash to the extent that it has more than is needed to maintain the business, giving it free cash flow to enable strategic acquisitions and return of capital to shareholders.

Therefore, in addition to innovating around existing product platforms, ABI has become active on the M&A front. The acquisition of the research products division of Ambion provides ABI with a leverage point to grow out its overall consumables business. The company also acquired Agencourt Personal Genomics' next-generation technology for DNA analysis, which it plans to introduce to early access customers in the middle of this calendar year. The company feels the platform it is developing from Agencourt's technology will enable it to maintain its leadership position across the sequencing market and be useful for gene expression, genotyping, as well as emerging research applications.

ABI will continue to expand new market opportunities; it has been successful in cultivating the global market for DNA forensics and human identification. Growth in ABI's forensics business is being driven by the adoption of DNA databasing through state and federal legislation throughout the world. For example, ABI has been working with Chinese government authorities to help them achieve their goal of having 1.2 million criminals in their national database by 2008 as well as their national goal to install more than 300 forensic DNA labs nationwide. Such expansion of the forensic market in China serves as one example of how ABI is positioning itself to benefit from the growth opportunity within these emerging markets.

Year to date, 57% of ABI's fiscal year 2007 revenue has been recognized outside of the US. The company will seek to generate more growth outside of the US , and is already seeing increased fiscal 2007 year-to-date revenue growth versus the prior year period in Europe (up 14%), Japan (up 7%), other Asia Pacific countries (up 32%), Latin America & other locales (up 29%).

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