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Expand Microplate Assay Capabilities
Expand microplate assay capabilities with Molecular Devices’ multimode and single-mode readers and data-analysis software. The SpectraMax M5e is a tunable, monochromator-based system for medium-throughput screening and assay development. An integrated pipettor option (FlexStation 3) and 50-plate stacker (StakMax) are also available. SoftMax
Pro 5 GxP software analyzes and validates bioassays without exporting data to third-party software packages and is GLP/GMP compliant.
Vendor: Molecular Devices Corporation
Products: SpectraMax M5e microplate reader; SoftMax Pro 5 GxP data-analysis software
Available: Now
For more information:
www.moleculardevices.com
In-Vivo Multispectral Imaging System
Kodak’s In-Vivo Multispectral imaging system is capable of detecting disease at a very early stage. The system incorporates workflow automation and advanced multispectral fluorescence, luminescence, digital x-ray, and radioisotopic imaging capabilities. Excitation wavelengths ranging from optical through near-infrared enable researchers to optimize imaging of a wide range of fluorochromes and biomarkers.
Vendor: Eastman Kodak Company
Product: In-Vivo Multispectral system
Available: Worldwide availability is expected in spring of 2007
For more information: www.kodak.com/go/molecular
BD Fluorescent Dyes
Detect live cells and key functional activities in a variety of cell-based assays with fluorescent dyes. BD Calcein AM and BD DiIC12(3) Fluorescent Dyes can be used with BD Falcon FluoroBlok Cell Culture Inserts and Insert Systems to label cells when performing analyses such as tumor cell invasion, endothelial cell migration, endothelial cell tubulogenesis, and other cell-based assays.
Vendor: BD Biosciences
Product: Fluorescent dyes
Available: Now
For more information: www.bdbiosciences.com/fluorescentdyes
Integrated and Ad Hoc Reporting from Almac
Almac has added new integrated and ad hoc reporting capabilities to its offerings for the clinical trial market. A single Web site houses data and reports from its affiliated companies, Almac Clinical Technologies and Almac Clinical Services. Reports on the Web site offer drug and trial information, and include reports with integrated data from both companies. In addition, a new ad hoc reporting tool enables users to create their own custom reports using a simple report creation tool.
Vendor: Almac
Product: Integrated and ad hoc reporting
capabilities
Available: Now
For more information: www.almacgroup.com
AdenoSilence Vectors for RNAi Delivery
Millipore’s first round of adenoviral shRNA expression vector reagents targeting the human druggable genome includes the major protein classes amenable to small-molecule intervention. AdenoSilence vectors allow for single-step delivery of shRNA through the direct application of the virus supernatants onto a primary cell culture. AdenoSilence reagents typically silence the gene of interest for more than ten days.
Vendor: Millipore Corporation
Product: AdenoSilence vectors
and reagents
Available: Now
For more information: www.millipore.com
Molecular Tools for Drug Discovery
Applied Biosystems launched a new series of TaqMan Gene Signature Panels for accelerating drug discovery research. TaqMan provides over 2,400 unique assays to detect polymorphisms in 220 genes that code for various drug metabolism enzymes and drug transporters. Researchers can simultaneously observe and determine the expression level of genes that encode proteins involved with critical cellular functions, identify potential new drug targets, validate known targets, and screen samples during drug development. Significant proteins addressed by the new gene signature panels include G-protein coupled receptors (GPCRs). The TaqMan array’s micro fluidic cards allow researchers to perform 384 simultaneous real-time PCR reactions. Determining the function of ATP-binding cassette (ABC) transporters, enables researchers to test mechanisms that regulate the transport of substances across the cell membrane, mediate export of drugs in tumor cells, and affect drug resistance.
Vendor: Applied Biosystems
Product: TaqMan Gene Signature Panels
Availability: Now
For more information: www.appliedbiosystems.com
Detect Drug Effects on Tubular Tissues
Biopta’s PM-1 is an automated perfusion and wire myograph incorporating the company’s Perf-Exion optical technology, which allows detection of the external and internal dimensions of tubular biological structures. PM-1 is designed to capture information from isolated blood vessels. Up to four individually regulated tissues provide information on drug potency, and efficacy from sensitive measurement of changes in tissue diameter, flow, pressure, and force production.
Vendor: Biopta
Product: PM-1
Available: Now
For more information:
www.biopta.com
BeadChips to Access Genetic Variations
Illumina, Inc. announced the next BeadChips in its Infinium product family that profiles over one million diverse genetic variants. The Human 1M BeadChip combines a level of content for both whole-genome (WG) and copy number variation (CNV) analysis, along with additional, high-value genomic regions of interest on a single microarray chip. The Human 1M BeadChip combines higher tagSNP coverage than the HumanHap650Y BeadChip, adding several hundred thousand individually-selected SNPs in genes and functional areas. The introduction of the Human 450S BeadChip will enable customers using Illumina’s HumanHap550 BeadChip to extend their genetic studies to include the one million content level. The Human 1M and Human 450S BeadChips are powered by Illumina’s Infinium Assay, providing high density genomic coverage, and intelligent probe selection.
Vendor: Illumina
Product: Human 1M and Human 450S
BeadChips
Availability: Second quarter 2207
For more information: www.illumina.com
Preclinical Multiplex
Toxicity Screening
Beckman Coulter’s GenomeLab GeXP Rat MultitoxPlex Kit contains 25 genes involved in key toxicological pathways including toxicity, stress, DNA damage, and apoptosis. Three reference genes and one internal standard are included. The new kit and the GenomeLab GeXP Genetic Analysis System deliver multiplexed, quantitative analysis of genes from hundreds of samples at a time. Researchers may also add their own genes of interest to the new Rat MultitoxPlex panel.
Vendor: Beckman Coulter
Product: GenomeLab GeXP Rat MultitoxPlex Kit
Available: Now
For more information: www.beckmancoulter.com
Caliper Launches Services Business
Caliper Discovery Alliances & Services offers more than 700 in vitro assay types, including receptor, enzyme, and ion channel screening and profiling assays, side effect and ADME-tox panels, and cellular models for immunology, oncology, and other fields. In vivo offerings include more than 85 pharmacological assays that measure over 400 different parameters for applications such as in vivo compound profiling and phenotyping, and target validation studies.
Vendor: Caliper Life Sciences
Product: Caliper Discovery Alliances
& Services (CDAS)
Available: Now
For more information: www.caliperls.com
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